Identification of reproductive genes by gene targeting strategies
نویسندگان
چکیده
Reproduction is a process delicately choreographed to ensure the survival of species. In terms of precision and beauty, reproductive physiology is just as amazing as the flamboyant display of reproductive behaviors. Any misstep during the scripted development of functional gonads and gametes may result in reduced fertility or infertility. Fertility disorders in human are a major health problem and also distressing experience for couples expecting children in their life. For diagnostic purposes, some genetic analyses for known defects and other tests are conducted in fertility clinics. However, almost a quarter of infertility cases are idiopathic, depicting our lack of knowledge in the underlying mechanisms of reproduction. Although assisted reproduction is widely available in the clinics to help these couples, quite a few infertile women still fail to become pregnant. Even when the procedures are successful, there are also substantial risks associated with the passing of defective genes to their children.
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